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THE SEX OF A PERSON IS DETERMINED BY THEIR SEX CHROMOSOMES & PRIMARY SEX CHARACTERISTICS

SEX CHROMOSOMES

Nearly 100% of humans are either FEMALE (XX sex chromosomes) or MALE (XY sex chromosomes)

PRIMARY SEX CHARACTERISTICS

XX human / woman (LEFT) XY human / man  (RIGHT)

    EXCEPTION TO THE RULE:

    INTERSEX HUMANS

    Far less than 1% of humans have a sex chromosome makeup that is NOT XX (female) or XY (male) AND/OR "ambiguous" sex characteristics

    Refernce

    Intersex Example #1: XXY sex chromosomes

    Klinefelter's Syndrome

    The person has two XX sex chromosomes and one Y sex chromosome


    One in 500 to 1,000 "male" newborns. Klineflelter's Syndrome is the most common type of Intersex.

    Reference

    The presence of the extra X chromosomes may affect a broad range of conditions including, but not limited to, social skills, behavioral issues, infertility, hormone production, low muscle tone, problems with coordination, speech delays, learning disabilities and limited problem solving skills (executive functioning), gynecomastia, osteoporosis, anxiety and depression" 

    Reference

    The most common type of Intersex is Klinefelter's Syndrome - 3 sex chromosomes - one Y and two Xs. The extra X sex chromosomes causes physical differences - some examples are pictured. However, they can vary significantly! In fact, 25% to 50% of people with Klinefelter's Syndrome are diagnosed. 

      Intersex Example #2: Only 1 sex chromosome

      Turner's Syndrome

      A person with Turner's Syndrome has two only one sex chromosome, an X


      One in 2,000 female newborns

      Having only an X chromosomes may affect a broad range of conditions including, but not limited to, a short stature, a short & wide neck, a broad chest and widely spaced nipples, arms that turn out slightly at the elbows, a low hairline, failure of teeth to develop normally, a large number of moles, small & spoon-shaped nails, a short 4th finger or toe, osteoporosis, scoliosis, under-active thyroid, impaired vision, congenital heart defect or narrowing of the aorta

      Reference

      Another type of Intersex is Turner's Syndrome. This person has only 1 sex chromosome - an X from the mother (none from the father). The sex chromosome anomaly causes physical and health differences - some examples are pictured. 

      Intersex Example #3: "XX Male"

      XX Male Syndrome or de la Chapelle Syndrome

      One in 20,000 newborn boys.


      "Males" born with XX chromosomes are genetically females, but present as male. However, the masculinization of XX males is variable.


      Caused by a mutation of a sex chromosome.

      Reference

      Intersex Example #4: "XY Female"

      Swyer Syndrome

      One in 80,000 humans.


      "Females" born with XY chromosomes are genetically males, but for a variety of reasons – mutations in genes that determine sexual development – the male characteristics are never expressed. 


      "XY females"  live their lives as girls and then women, and a few can even give birth.

      Reference

      Males and females who "identify as transgender" or "non-binary" have either XX or XY sex hormones

      They are NOT intersex !

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